Evidence-based tools and references to help Minnesotans understand psychedelic science, policy, and public health.
Resources
Science & Clinical Research
Policy & Regulatory Models
Public Health & Harm Reduction
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Highly accessible summaries of historical, clinical, and experiential research used by policymakers nationwide. Learn more here.
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Research summaries, substance profiles, harm-reduction guidance, and policy perspectives for a general audience. Visit MAPS.
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Accessible writing on news, research summaries, cultural context, and emerging psychedelic discourse.
Learn more.
Introduction & General Education
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Minnesota’s Psychedelic Medicine Task Force was established by the Legislature in 2023 to advise on the legal, medical, and policy issues associated with potential psychedelic medicine legalization. The MDH page includes task force membership, meeting materials, public input opportunities, and the task force’s official reports and recommendations to the Legislature.
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View recordings of Psychedelic Medicine Task Force meetings.
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The Psychedelic Society of Minnesota is a 501(c)(3) nonprofit community organization that aims to promote and conduct education, harm reduction, research, and drug policy reform around psychedelics
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Big Psych MPLS is a community-rooted education and connection hub that supports cultivating a direct and respectful relationship with the natural world.
Minnesota-Specific Resources
Policy & Regulatory Models
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The first regulated psilocybin program in the U.S. Includes rulebooks, licensing requirements, facilitator training standards, and public-health frameworks. Oregon Psilocybin Services.
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Early regulatory structure for natural medicines, including advisory recommendations and rulemaking processes. Colorado Natural Medicine Division.
Science & Clinical Research
Research Institutions
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Overview of modern clinical trials and mechanistic research.
Covers safety, therapeutic models, and the science behind psilocybin in depression, anxiety, addiction, and end of life care.
Source: www.hopkinsmedicine.org/psychiatry/research/psychedelics-research
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Provides research, public education, and journalism on the science, ethics, and policy implications of psychedelics with clear, accessible reports helpful for legislative decision making.
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Publishes peer reviewed research on the therapeutic use, risks, and neuroscience of psychedelics, including studies relevant to public health and regulatory frameworks.
https://med.nyu.edu/departments-institutes/psychiatry/research/psychedelic-medicine
Scientific Summaries & Meta Analyses
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Publishes clinical trial results including comparisons between psilocybin therapy and existing antidepressants.
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A leading peer reviewed journal with rigorous research on psychedelic safety, mechanisms, and therapeutic outcomes.
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Open access, high quality studies reviewing clinical effects, risks, and emerging evidence.
https://journals.plos.org/plosmedicine/search?filterJournals=PLoSMedicine&q=Psychedelics
Scientific Publications
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JAMA Psychiatry, 2023
A top level review of how psychedelics are being studied across mental health conditions, how dosing sessions work, and what early clinical evidence shows.
Source: www.jamanetwork.com/journals/jama/fullarticle/2808951
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Frontiers in Psychology, 2025
Comprehensive and accessible review of how classic psychedelics work in the brain, pharmacology, subjective effects, safety profiles, and the importance of set and setting.
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Preprint, 2024
Explains how psychedelics influence brain plasticity, neural growth, and emotional processing. Useful for understanding therapeutic potential.
Source: https://arxiv.org/abs/2411.19840
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Neuroscience and Biobehavioral Reviews, 2025
Summarizes what users commonly describe: insight, emotional release, meaning making, perceptual change, mystical type experiences. Highlights the role of context.
Source: https://www.sciencedirect.com/science/article/pii/S0149763425001174
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Current Psychiatry Reports, 2025
Explores the gap between controlled research settings and real world therapeutic use. Useful for policy considerations, training, and standards.
Public Health & Harm Reduction
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Federal summaries of what is known and not known about psychedelics, including safety data.
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Widely used non-clinical de-escalation and peer support model adapted by many jurisdictions.
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DanceSafe provides evidence-based drug checking, safety education, and peer-led harm-reduction services designed to reduce preventable risks in nightlife and festival settings.
